A Theory for Allosteric Temperature-Sensitive Transcription Factors

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2018
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Swarthmore College. Dept. of Physics & Astronomy
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en
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Full copyright to this work is retained by the student author. It may only be used for non-commercial, research, and educational purposes. All other uses are restricted.
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Abstract
We propose a theory for temperature-sensitive transcription factors under the allostery framework. We show that the allostery theory due to excess vibrational entropy and conformational energy difference can produce a thermal switch behavior that is experimentally observed in the literature. The theory paves the way for a complete model of a tunable thermal bioswitch.
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