The Effects of Neonatal Surgical Pain and Stress on Adulthood Pain Response, Stress Response, and Learning & Memory in Mice

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2006
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Haverford College. Department of Psychology
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Thesis
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Award
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eng
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Haverford users only
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Abstract
Using a mouse model of neonatal surgery, we attempted to determine whether the effects of neonatal pain are mediated by the stress response. Half the subjects that received a real or sham surgery were treated after the procedure with buspirone, a 5HT1A receptor antagonist with reported anxiolytic properties. The other half received a control injection of saline. We tested the effects of sex, age, surgical condition, and drug condition on adulthood behaviors of pain sensitivity, baseline anxiety, stress-induced anxiety, and learning and memory, as well as c-fos expression in brain structures related to stress and learning. Results from hot plate latency data revealed an affect of neonatal pain that was reversed by anxiolytic treatment. However, considering the number of variables involved and the uncertainty about the anxiolytic effectiveness of buspirone, we are unable to conclude with certainty that the stress response mediates the effects of neonatal pain.
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