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Browsing Chemistry by Issue Date

Browsing Chemistry by Issue Date

Now showing items 1-20 of 38

Overexpression, Purification, Spin-Labeling, and Characterization of Full-Length M2, an Integral Membrane Protein of Influenza A, in Detergent Micelles and in Mixed Lipid Vesicles

Chen, Richard (2013)

M2 is a 97-residue, multi-functional transmembrane protein that has been implicated in processes important to viral replication, such as proton conduction and viral budding of Influenza A. Due to experimental difficulties ...
Interaction of Ruthenium Polypyridyl Complexes With Human Telometric DNA

Tran, Vienna T. (2013)

The goal of this thesis work was to explore the interactions between a series of ruthenium complexes and the human telometric DNA sequence. Specifically, this work investigated the ability of [Ru(bpy)₂L]²⁺ and [Ru(phen)₂L]²⁺ ...
Utilizing Enantiopure Planar Chiral Sulfinyl and N-Oxazolidinyl Iron(O) Tricarbonyl Diene Complexes for the Installation of Adjacent Stereocenters

Wong, Alice Rose (2013)

Enantiomerically pure planar chiral iron(0) tricarbonyl diene complexes were used as a template for the diastereoselective spiroketalization of four spiroketals. As an additional complication, these substrates contained ...
Analysis of Beetle Cuticular Hydrocarbons

Williams, Elizabeth (2013)

The insect cuticle, commonly known as the exoskeleton, consists of two layers: a bottom layer called the procuticule and a thin outer waxy coating called the epicuticle. The epicuticle contains hydrocarbons that prevent ...
Jet-Cooled Spectroscopic Characterization of Anethole (methoxy-4-(prop-1-enyl)benzene), a Natual Styrene Derivative

Barber, Victoria (2013)

The molecular structure of anethole (methoxy-4-(prop-l-enyl)benzene), was investigated using Jet-Cooled UV spectroscopy. A laser-induced fluorescence spectrum was obtained of the S₁-S₀ transition. Two 0⁰₀ transitions were ...
Studies on the Diastereoselctive Synthesis of Spiroketals and Bis-spiroketals Utilizing a Planar Chiral Sulfinyl Diene Iron(0) Tricarbonyl Scaffold

Tracy, Jacob (2013)

Spiroketals are chemical motifs found in a range of natural products, many of which possess important biological activity. The stereochemistry of the spiro center of a spiroketal can be controlled by an enantiomerically ...
Investigating G-quadruplex Formation and its Structural Perturbation by and Interactions with N-methyl mesoporphyrin IX

Barrett, Steven P. (2013)

G-quadruplexes (GQs) are noncauonical secondary structures of DNA that can adopt a multitude of different topologies. Here, we explore the factors that drive the formation of these structures and favor the specific ...
Characterizing the Interactions Between Influenza A M2 Protein and Cholesterol in Membranes

Elkins, Matthew (2014)

The influenza A M2 protein is 97-residues in length and homotetramerizes to form a proton channel across the viral membrane early in the influenza life cycle. M2 is also implicated in the formation and budding of new viral ...
Probing and Characterizing Different Conformations of the Influenza A M2 Protein Using SDSL-EPR Spectroscopy

Kim, Sangwoo Shawn (2014)

The M2 protein is a 97-residue membrane homotetrameric protein found on the viral coat of the Influenza A virus. M2 plays a key role in virulence of the Influenza A virus. M2 was previously shown to act as a proton channel ...
SDSL-EPR Structural Studies of the Cytoplasmic Helix in Novel Full-Length Constructs of the Influenza A M2 Protein

Thompson, Megan (2014)

The M2 protein of the influenza A virus is a homotetrameric transmembrane proton channel implicated in several stages of the viral replication process. Each of its 97-residue monomers is known to include a transmembrane ...
Investigation of Porphyrins as Potential G-Quadruplex Stabilizing Ligands and Fluorescent Probes

Sabharwal, Navin C. (2014)

G-quadruplex (GQ) DNA is a non-canonical DNA structure thought to form throughout the human genome. Because the stabilization of quadruplexes formed in the telomeres and in the promoters of oncogenes may prevent the spread ...
Using Planar Chiral Iron(0) Tricarbonyl Diene Complexes: A Focus on Azaspirocycles and the Use of an Oxazolidinone Chiral Auxiliary

Murphy, Julia Saxton (2015)

For many years, the Paley laboratory has developed the use of planar chiral1l4 iron(O) tricarbonyl complexes for use in directing the central chirality of adjacent centers. This work examines the use of dienes functionalized ...
Studies on two putative AI-2 receptors and the transcriptional repressor LsrR

Hua, Jason (2015)

A diverse range of Gram-negative and Gram-positive bacteria rely on density-dependent, intercellular communication mediated by small signaling molecules called auto inducers to coordinate synchronous gene expression ...
A Diastereoselective Approach to Bis-spiroketal Synthesis Using Sulfinyl Iron(0) Tricarbonyl Diene Complexes

Amadeo, Peter (2015)

In the past, Paley lab has focused on the diastereoselective synthesis of spiroketals using sulfinyl ironeD) tricarbonyl diene complexes. This research has extended to study the formation of bis-spiroketals. As valuable ...
Enantiomerically Pure Planar Chiral N-Oxazolidinoyl Diene Tricarbonyl Iron(O) Complexes: Their Synthesis and Functionalization

Quevedo, Raundi (2016)

Broadly, the goal of this research was to observe the scope of the molecules we could make, how effective the syntheses were, and what the broader outcomes were. One objective of this research was to observe how oxazolidinoyl ...
Investigations of the Quorum Sensing Repressor LsrR from Escherichia coli and Salmonella Typhimurium and the Putative AI-2 Receptor LsrB from Clostridium antoethanogenum

Kissman, Elijah N. (2018)

Quorum sensing is a process by which bacteria coordinate community behaviors through the exchange of signal molecules. Both Gram-negative and Gram-positive bacteria use quorum sensing to regulate cell density-dependent ...
Conformation and Directionality of the Influenza A M2 Protein Domain Essential to Viral Replication

Raymond, Hayley (2018)

Influenza A causes seasonal epidemics, and the possibility of another worldwide influenza A pandemic remains a public health concern. The influenza A M2 protein is implicated in the virus’s ability to bud and create new ...
Spectroscopic and Crystallographic Characterization of Enantiopure Planar Chiral N-Oxazolidinoyl Diene Iron (O) Tricarbonyl complexes For Use in Diastereoselective Synthesis

Dow, Nathan W. (2018)

Iron(D) tricarbonyl-diene complexes have emerged from the field of organometallics as motifs of particular importance due to their robust synthetic applications. As a result of their planar chiral configurations, these ...
Investigations of the Putative AI-2 Receptor Protein LsrB from Thermobacillus composti and Truncations of the Salmonella enterica ser. Typhimurium LsrE Protein

Petty, Nicholas E. (2018)

Bacteria were believed to exist as solitary, unicellular organisms until about 50 years ago with the discovery of quorum sensing by John Woodland Hastings. Since then, numerous studies have examined the broad reaching ...
Pitch Measurements in a Chiral Lyotropic Chromonic Liquid Crystal: Temperature and Dopant Concentration Dependence of the Pitch

Ogolla, Timothy (2018)

The antihistamine, disodium cromoglycate (DSCG), forms a nematic (N) phase in which the molecules are stacked like a pile of cards to form columnar assemblies; addition of a small amount of chiral molecules can form a ...

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