Non-canonical DNA structures known as G-quadruplexes (GQs) and i-motifs can form from G-rich and C-rich sequences within the genome, respectively, which are prominent within telomeres and oncogene promoters. These non-canonical ...
G-quadruplexes (GQs) are non-canonical DNA structures composed of stacks of
stabilized guanine tetrads (G-tetrads). GQs are highly diverse structures that can be
categorized by their strand directionality, number of ...
The goal of this thesis work was to explore the interactions between a series of
ruthenium complexes and the human telometric DNA sequence. Specifically, this
work investigated the ability of [Ru(bpy)₂L]²⁺ and [Ru(phen)₂L]²⁺ ...
G-quadruplexes (GQs) are noncauonical secondary structures of DNA that can adopt a
multitude of different topologies. Here, we explore the factors that drive the formation of
these structures and favor the specific ...
This work focuses on the structure and interactions with ligands of noncanonical
DNA structures. These noncanonical structures include guanine quadruplexes (GQs), as
well as a novel type of quadruple helix. Sequences ...
G-quadruplex (GQ) DNA is a non-canonical DNA structure thought to form throughout the human genome. Because the stabilization of quadruplexes formed in the telomeres and in the promoters of oncogenes may prevent the spread ...
DNA replication is an essential process for the survival of all organisms. Errors
can occur during the process that leads to replication stress, which can promote genomic
instability, a hallmark of cancer. The Brown lab ...