Browsing by Subject "Hypothalamus"
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- ItemThe Neurobiological Etiology of Postpartum Depression: The Role of Oxytocin in the Hypothalamus and the Amygdala(2017) Bodie, Clio; Been, LauraIn the current study, we simulated the hormonal conditions of pregnancy and a postpartum period in a Syrian hamster model in order to better understand the neurobiological etiology of postpartum depression (PPD). PPD is a distinct subtype of major depressive disorder, which develops in new mothers during the first few weeks after delivery. It is a prevalent disorder and has incredibly harmful effects on both the mother and her infant, but not much is understood about its etiology, which makes treatment difficult. We hypothesized that after estrogen withdrawal produced a PPD-like state, subjects would show behavioral indicators of anhedonia through the Sucrose Preference Test. We also expected to find decreased levels of oxytocin producing cells in the paraventricular nucleus of the hypothalamus (PVN) and the medial amygdala of animals that experienced hormone withdrawal, which we believed might contribute to the development of PPD. We did not find any significant differences in the behavioral measures testing anhedonia. Our neurobiological findings were the opposite of what we hypothesized- we found significantly higher quantities of oxytocin producing neurons in the PVN of hamsters that experienced hormone withdrawal. These findings may indicate that oxytocin contributes to dysregulation of the HPA axis in the postpartum or that oxytocin fluctuations within the postpartum period affect PPD. Future research should further explore the role of oxytocin in the hypothalamus and amygdala, as it appears to be associated with PPD.
- ItemThe Neurobiological Mechanisms of Postpartum Depression: The Role of Oxytocin in the Hypothalamus and Amygdala(2017) Amaral, Claudia F.; Been, LauraAlthough postpartum depression has a prevalence of approximately 15% and can result in negative outcomes for both the mother and her child, its underlying neurobiological mechanisms remain mostly unknown. Previous research suggests that ovarian hormone fluctuations that occur during the postpartum period could underlie depressive symptoms in postpartum depression. Studies have also suggested that changes in oxytocin signaling could also play a role in the etiology of this disorder. The present study adapts the ovarian withdrawal model of postpartum depression to a Syrian hamster animal model in order to study the neurobiological mechanisms of postpartum depression. Its aim is to test whether hormone withdrawal during the postpartum period results in changes in oxytocin signaling between the paraventricular nucleus and the medial amygdala. It is hypothesized that these neurobiological changes could be implicated in depressive-like behavior during the postpartum period.